Eligibility Criteria

Inclusion Criteria:

1. Male and female between the ages of 21 and 30 years

2. Medically and neurologically healthy on the basis of history, physical examination,
EKG, screening laboratories, absence of current and/or past substance abuse

3. For Family History Positive (FHP) Subjects: Biological father and another first or
second-degree biological relative with history of alcoholism

Exclusion Criteria:

1. DSM-IV psychiatric and substance abuse diagnosis by history on psychiatric evaluation
that includes a structured diagnostic interview (The Semi-Structured Assessment for
the Genetics of alcoholism: SSAGA) and the Wisconsin Scales of Psychosis Proneness

2. History of counseling or psychotherapy; except family therapy centered around another
family member

3. Extended unwillingness to remain alcohol-free for three days prior to testing and for
the duration of the testing period

4. For women: positive pregnancy test at screening or intention to engage in unprotected
sex during the study

5. Alcohol naïve

6. Previous bad experience with ketamine

7. Adoptee and no contact with family members

8. For Family History Negative (FHN) Subjects: NO family history of alcoholism in any
first or second-degree relatives (subjects must reliably report on three first-degree
relatives)