GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

What is the purpose of this trial?

Who can participate?

Ages Eligible: 21 Years - 30 Years
Gender Eligible: Both
This trial accepts healthy volunteers

Inclusion Criteria:

1. Male and female between the ages of 21 and 30 years

2. medically and neurologically healthy on the basis of history, physical examination,
Electrocardiogram (EKG), screening laboratories

3. absence of any evidence of substance abuse (with the exception of nicotine
dependence) on the basis of history and drug and ethanol-free at the time of testing
based on urine toxicology and breath alcohol levels at screening and on each test
day.

Exclusion Criteria:

1. Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) Axis I
psychiatric and substance abuse or dependence diagnosis by history on psychiatric
evaluation that includes a structured diagnostic interview (SCID)

2. unwillingness to remain alcohol-free for three days prior to each test day;

3. for women, positive pregnancy test at screening or intention to engage in unprotected
sex during the study and

4. alcohol naive. For Family History Positive Subjects: 1) Biological father and another
first or second-degree biological relative with history of alcoholism by Family
History Assessment Module (FHAM) developed by COGA.

For Family History Negative Subjects: NO family history of alcoholism in any first or
second-degree relatives. Subjects must reliably report on three first-degree relatives.

What is the purpose of this trial?

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Who can participate?

Ages Eligible: 21 Years - 30 Years
Gender Eligible: Both

Inclusion Criteria:

1. Male and female between the ages of 21 and 30 years

2. medically and neurologically healthy on the basis of history, physical examination,
Electrocardiogram (EKG), screening laboratories

3. absence of any evidence of substance abuse (with the exception of nicotine
dependence) on the basis of history and drug and ethanol-free at the time of testing
based on urine toxicology and breath alcohol levels at screening and on each test
day.

Exclusion Criteria:

1. Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) Axis I
psychiatric and substance abuse or dependence diagnosis by history on psychiatric
evaluation that includes a structured diagnostic interview (SCID)

2. unwillingness to remain alcohol-free for three days prior to each test day;

3. for women, positive pregnancy test at screening or intention to engage in unprotected
sex during the study and

4. alcohol naive. For Family History Positive Subjects: 1) Biological father and another
first or second-degree biological relative with history of alcoholism by Family
History Assessment Module (FHAM) developed by COGA.

For Family History Negative Subjects: NO family history of alcoholism in any first or
second-degree relatives. Subjects must reliably report on three first-degree relatives.

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Additional Location

Connecticut