Eligibility Criteria

Inclusion Criteria:

1. Male and female between the ages of 21 and 30 years;

2. medically and neurologically healthy on the basis of history, physical examination,
EKG, Screening laboratories absence of current and/or past substance abuse on the
basis of history and urine toxicology and breath alcohol levels at screening and on
each test day.

For Family History Positive (FHP) Subjects: 1) Biological father and another first or
second-degree biological relative with history of alcoholism by FHAM-Family History
Assessment Module developed by COGA.

Exclusion Criteria:

1. DSM-IV psychiatric and substance abuse (excluding alcohol abuse) diagnosis by history
on psychiatric evaluation that includes a structured diagnostic interview (Structured
Clinical Interview for DSM-IV Axis I Disorders: SCID)

2. Subjects who meet criteria for alcohol abuse and express an interest in stopping
alcohol use and/or express an interest in treatment or are currently enrolled in
treatment for alcoholism, or have sought treatment in the last 6 months.

3. history of counseling or psychotherapy; except family therapy centered around another
family member

4. extended unwillingness to remain alcohol-free for 48 hours prior to test days;

5. for women: positive pregnancy test at screening or intention to engage in unprotected
sex during the study

6. alcohol naïve

7. Adoptee and no contact with family members.