Condition:
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high risk individuals that may lead to the transition from moderate to excessive use of alcohol.
Dates: March 2001 -
Study Status: Recruiting
Ages Eligible: 21 Years - 30 Years
Gender Eligible: Both
This trial accepts healthy volunteers
Inclusion Criteria:
For Family History Positive (FHP) Subjects: 1) Biological father and another first or second-degree biological relative with history of alcoholism by FHAM-Family History Assessment Module developed by COGA.
Exclusion Criteria:
Sponsor:
First Received: December 27, 2007
Last Updated: Feb 07, 2009
Clinicaltrials.gov ID:
NCT00612352
Study HIC # 0304025194
Condition:
Intervention: Drug: 0.1 and 0.04 ethanol doses - IV
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high risk individuals that may lead to the transition from moderate to excessive use of alcohol.
Dates: March 2001 -
Study Status: Recruiting
Ages Eligible: 21 Years - 30 Years
Gender Eligible: Both
Inclusion Criteria:
1. Male and female between the ages of 21 and 30 years;
2. medically and neurologically healthy on the basis of history, physical examination,
EKG, Screening laboratories absence of current and/or past substance abuse on the
basis of history and urine toxicology and breath alcohol levels at screening and on
each test day.
For Family History Positive (FHP) Subjects: 1) Biological father and another first or
second-degree biological relative with history of alcoholism by FHAM-Family History
Assessment Module developed by COGA.
Exclusion Criteria:
1. DSM-IV psychiatric and substance abuse (excluding alcohol abuse) diagnosis by history
on psychiatric evaluation that includes a structured diagnostic interview (Structured
Clinical Interview for DSM-IV Axis I Disorders: SCID)
2. Subjects who meet criteria for alcohol abuse and express an interest in stopping
alcohol use and/or express an interest in treatment or are currently enrolled in
treatment for alcoholism, or have sought treatment in the last 6 months.
3. history of counseling or psychotherapy; except family therapy centered around another
family member
4. extended unwillingness to remain alcohol-free for 48 hours prior to test days;
5. for women: positive pregnancy test at screening or intention to engage in unprotected
sex during the study
6. alcohol naïve
7. Adoptee and no contact with family members.
Sponsor:
First Received: December 27, 2007
Last Updated: Feb 07, 2009
Clinicaltrials.gov ID:
NCT00612352
Study HIC # 0304025194
Petrakis, Ismene Leonida
Principal Investigator
HIC # 0805003779
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