Diseases and Conditions Researched
Down Syndrome; Leukemia
What is the purpose of this trial?
RATIONALE: Studying the genes expressed in samples of blood from patients with Down syndrome may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood samples from newborns with Down syndrome.
Participation Guidelines
Age:
Up to 1 Year
Gender: Both
Click here for
detailed participation information for this trial.
|
Sponsors:
|
Children's Oncology Group; National Cancer Institute (NCI) |
| Dates: |
August 13, 2009 |
| Last Updated: |
December 21, 2011 |
| Study HIC#: |
1112009391 |
| Clinicaltrials.gov ID: |
NCT00959283
|
Conditions
Down Syndrome; Leukemia
Interventions Details
| Genetic:
|
DNA analysis |
| Genetic:
|
RNA analysis |
| Genetic:
|
cytogenetic analysis |
| Genetic:
|
fluorescence in situ hybridization |
| Genetic:
|
gene expression analysis |
| Other:
|
flow cytometry |
| Genetic:
|
microarray analysis |
| Genetic:
|
mutation analysis |
| Genetic:
|
polymerase chain reaction |
| Genetic:
|
polymorphism analysis |
| Other:
|
laboratory biomarker analysis |
| Other:
|
pharmacological study |
Trial Purpose
RATIONALE: Studying the genes expressed in samples of blood from patients with Down syndrome may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood samples from newborns with Down syndrome.
Participation Guidelines
Age:
Up to 1 Year
Gender: Both
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of transient myeloproliferative disorder (TMD) at < 90 days of age and
meeting 1 of the following criteria:
- A diagnosis of Down syndrome or Down syndrome mosaicism AND non-erythroid and
non-lymphoid blasts (any amount) in the peripheral blood verified with a second
sample
- Patients with typical physical characteristics of Down syndrome are allowed
before cytogenetic or FISH confirmation of the diagnosis
- Trisomy 21-positive leukemic blasts documented by biopsy of any organ (including
> 5% non-erythroid/non-lymphoid blasts documented by bone marrow aspirate or
biopsy)
- Infants with isolated trisomy 21 positivity identified only in the leukemic
blasts are allowed
- Institutional immunophenotype characterization is required for study enrollment
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Link
|
Sponsors:
|
Children's Oncology Group; National Cancer Institute (NCI) |
| Dates: |
August 13, 2009 |
| Last Updated: |
December 21, 2011 |
| Study HIC#: |
1112009391 |
| Clinicaltrials.gov ID: |
NCT00959283
|