Eligibility Criteria

Inclusion Criteria:

- recurrent or persistent vulvar Paget's disease with overexpression of HER2 by
immunohistochemistry and or fluorescence in situ hybridization (FISH)

- Biopsy for histologic confirmation

- Measurable disease

- Karnofsky score of 50-100

- recovered from effects of recent surgery, radiotherapy, or chemotherapy

- free of active infection requiring antibiotics

- adequate bone marrow function,renal function,hepatic function,cardiac
function,WOCBP-neg.serum pregnancy,meet requirements in section 7.0

Exclusion Criteria:

- no measurable disease

- tumors not HER2 positive by immunohistochemistry FISH

- prior therapy with any anti-HER2 monoclonal antibody preparation

- Karnofsky score of 0-40

- other invasive malignancies, with the exception of non-melanoma skin cancer

- Patients requiring supplemental oxygen

- unstable medical conditions in the opinion of the treating physician place them at
unacceptably increased risk from trastuzumab therapy

- Patients with active or unstable cardiac disease, or myocardial infarction within 6
months