Eligibility Criteria

Inclusion Criteria:

1. Male and females, between the ages of 18 and 55

2. Are using cocaine more than once per week in the previous 30 days, provide a
cocaine-positive urine specimen at screening, and fulfill criteria for current
cocaine dependence according to DSM-IV

3. For women of child-bearing age, have a negative pregnancy test at screening, agree to
adequate contraception to prevent pregnancy, and agree to have monthly pregnancy
tests

4. Are fluent in English and have a 6th grade or higher reading level; AND

5. Can commit to at least 12 weeks of treatment and are willing to be randomized to
treatment

Exclusion Criteria:

1. Meet DSM-IV psychiatric classifications for lifetime schizophrenia or bipolar
disorder, or have a depressive or anxiety disorder with current use of a prescribed
psychotropic medication that cannot be discontinued

2. Current DSM-IV diagnosis of drug or alcohol dependence (other than cocaine, or
tobacco)

3. Demonstrate significant medical conditions, including asthma or chronic obstructive
lung disease, history or current gastrointestinal ulcer, hepatic or renal deficit and
cardiac rhythm disturbances or any other medical conditions that the study physician
deems contraindicated for galantamine treatment

4. Use of other medications including:

- drugs that slow heart rate (e.g., beta-blockers), which may increase the risk of
bradycardia and atrioventricular (AV) block and

- non-steroidal anti-inflammatory drugs (NSAIDs); increased potential for
developing ulcers/active or occult gastrointestinal bleeding

5. Have a screening liver function test (AST or ALT) greater than 3 times normal; OR

6. Known allergy or adverse reaction to galantamine