An Open Label, International, Multi-Center, Phase I/IIA Study of Lenalidomide (Revlimid) and Romidepsin (Istodax) for Relapsed/Refractory Hodgkin Lymphoma, Mature T-Cell Lymphoma and Multiple Myeloma (RID Study)

Diseases and Conditions Researched

Hodgkin's Lymphoma; Multiple Myeloma; Non-Hodgkin's Lymphoma

What is the purpose of this trial?

  • To establish DLTs and an MTD for the combination of romidepsin and lenalidomide for patients with lymphoma; and of romidepsin, lenalidomide and dexamethasone for patients with myeloma.
  • To establish tolerability and feasibility at the recommended phase-II doses for the combination regimens.
  • To establish initial evidence of efficacy in each of the three treatment groups according to histological diagnosis.
  • To explore the immunological, histological and gene-expression correlates of disease response and drug toxicity.

Participation Guidelines

Age: Any

Click here for detailed participation information for this trial.

Sponsors: Celgene Corporation; Yale Cancer Center
Last Updated:
Study HIC#: 1112009392