Genomic Research in Sarcoidosis
Diseases and Conditions Researched
What is the purpose of this trial?
This project is designed to address the following hypothesis:
Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription.
The Specific Aims are:
- To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes.
- To determine whether patterns in the lung microbiome are associated with sarcoidosis severity and disease phenotypes
- To correlate mRNA and microRNA expression patterns in sarcoidosis affected organs with changes in microbiome, clinical parameters and PBMC gene expression patterns
- To integrate clinical, transcriptomic, and microbiome data to identify novel molecular phenotypes in sarcoidosis.
Click here for detailed participation information for this trial.
|Sponsor:||University of Pittsburgh|
How will my information be used?
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If you're eligible to participate, you may be contacted by a nurse or study coordinator.
If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate.
In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile.