Genomic Research in Sarcoidosis

Diseases and Conditions Researched

Sarcoidosis

What is the purpose of this trial?

This project is designed to address the following hypothesis:

Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription.

The Specific Aims are:

  1. To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes.
  2. To determine whether patterns in the lung microbiome are associated with sarcoidosis severity and disease phenotypes
  3. To correlate mRNA and microRNA expression patterns in sarcoidosis affected organs with changes in microbiome, clinical parameters and PBMC gene expression patterns
  4. To integrate clinical, transcriptomic, and microbiome data to identify novel molecular phenotypes in sarcoidosis.

Participation Guidelines

Age: 18 Years - 85 Years
Gender: Both

Click here for detailed participation information for this trial.

Sponsor: University of Pittsburgh
Dates:
Last Updated:
Study HIC#: 1303011721