Diseases and Conditions Researched

Alzheimer's Disease

What is the purpose of this trial?

This study is based on the hypothesis that [11C]PIB (Pittsburgh Compound B) is a suitable tracer for imaging amyloid plaques in the brain. The main specific aims of this study are:

1.    a) To compare in vivo amyloid-ß burden as measured using [11C]PIB and PET in subjects with mild AD, subjects with MCI, and healthy controls.

b) To study the association between the neuropsychological test performance and [11C]PIB uptake in subjects with mild AD and MCI.

2.    a) To study in vivo amyloid-ß burden as measured using [11C]PIB and PET in healthy subjects with a family history of AD in a first degree relative and who are homozygous or heterozygous for the APOE ε4 and in subjects who lack this allele.

       b) To examine neuropsychological test performance in healthy subjects with family history of AD, as a function of APOE ε4 status

Participation Guidelines

Trial Purpose

This study is based on the hypothesis that [11C]PIB (Pittsburgh Compound B) is a suitable tracer for imaging amyloid plaques in the brain. The main specific aims of this study are:

1.    a) To compare in vivo amyloid-ß burden as measured using [11C]PIB and PET in subjects with mild AD, subjects with MCI, and healthy controls.

b) To study the association between the neuropsychological test performance and [11C]PIB uptake in subjects with mild AD and MCI.

2.    a) To study in vivo amyloid-ß burden as measured using [11C]PIB and PET in healthy subjects with a family history of AD in a first degree relative and who are homozygous or heterozygous for the APOE ε4 and in subjects who lack this allele.

       b) To examine neuropsychological test performance in healthy subjects with family history of AD, as a function of APOE ε4 status

Participation Guidelines