Eligibility Criteria

Inclusion Criteria:

• must be seeking treatment for alcohol drinking

• met DSM-IV TR Criteria for Alcohol Dependence

• smoke at least 5 cigarettes a day for the 6 months or more and have a CO of greater than 10ppm.

• report heavy drinking on at least 2 days on average per week (i.e.: more than 4 drinks on an occasion for women and 5 or more drinks for men) for the past 90 days and no more than 7 consecutive days of abstinence at study intake

Exclusion Criteria:

• exhibit current, clinically significant physical disease or abnormality based on medical history, physical examination, or routine laboratory evaluation

• have a history of cancer (except treated basal cell or squamous cell carcinoma of the skin)

• have a history of clinically signficant allergic reactions

• have a Body Mass Index (calculated as weight in kilograms divided by the square of height in meters) less than 15 or greater than 38 or weight less than 45 kg

• are a female of childbearing potential who is pregnant, nursing, or not practicing effective contraception (oral, injectable, or implantable contraceptives, intrauterine device, or barrier method with spermicide)