Glutathione and the aging brain

Trial Purpose and Description

The Specific Aims for this pilot study are: 1. To determine the feasibility of a study to quantify intracerebral levels of GSH as measured by 1H MRS at 4 Tesla in young and old individuals; 2. To begin defining the relationship between peripheral markers of metabolic status and intracerebral GSH; 3. To explore how aging alters the relationships between intracerebral GSH levels, human functional brain connectivity, and neurocognitive performance.

Ages: 18 years and older

Gender: Both


Eligibility Criteria

Age 18-35 or age 65-85 years.

Exclusion criteria
Diabetes, kidney, or liver disease. 
History of major heart disease. 
History of stroke or other neurologic and psychiatric diseases. 
Smoking.
Inability to enter MRI due to claustrophobia or metal in the body
For women: pregnancy, seeking pregnancy, or breastfeeding


National Institutes of Health

Dates: 10/26/2017 - 05/31/2020

Last Updated: 10/27/2017

Study HIC#: 2000021046

Get Involved

For more information about this study, contact:
Katherine Y Lam
+1 203-785-6430
wai.lam@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

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