Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)

What is the purpose of this trial?

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.


Participation Guidelines

Ages: 35 years and older

Gender: Both


National Institute of Neurological Disorders and Stroke

Dates: 07/20/2015 - 12/31/2020

Last Updated: 08/08/2015

Study HIC#: 1501015248

Get Involved

For more information about this study, contact:
Jacqueline Marie Gamberdella
+1 203-737-1899
jacqueline.gamberdella@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

Trial Image

Investigators

Carlos Ignacio Mena

Principal Investigator

Sub-Investigators